Eight volunteers find themselves fighting for their lives when a drug trial goes horribly wrong.

Frankenstein, a young medical students, trying to create the perfect human being, instead creates a misshapen monster. Made ill by what he has done, Frankenstein is comforted by his fiancée but on his wedding night he is visited by the monster. A fight ensues but the monster, seeing himself in a mirror, is horrified and runs away. He later returns, entering the new bride's room, and finds her alone.

When a young ski team training for the Olympics arrives at the remote and isolated Lost Mountain Ski Resort to focus on training, they're thrilled to find a retired Olympic skier is there to help them train. But their plans are halted when a scientist working at a nearby government lab arrives with the horrifying news that a top secret Government project has produced giant spiders and they have escaped, killing and eating everything in sight.

After losing contact with its researchers on a remote island, a military corporation hires a group of scientists and soldiers to find out what went wrong. When they arrive, the team quickly discovers that experiments performed on the island have unleashed a powerful and deadly entity that will stop at nothing to destroy them all.